The future of dendrimer drug delivery lies is fine tuning the carrier to incorporate variety of drugs and complex protein to ensure the vectorization of dendrimer-complex\conjugates to desired cells\tissues. The major focus will be on development of dendrimer based on new concept of biommetism\biomorphism with plasma stability and capability to target cell in various body compartments. Novel supramolecular structures based on polyethylene oxide copolymers and dendrimers are being intensively researched for delivery of genes and macromolecules. Hydrogels that can respond to a variety of physical, chemical and biological stimuli hold enormous potential for design of closed-loop drug-delivery systems. Design and synthesis of novel combinations of polymers will expand the scope of new drug-delivery systems in the future. 

References

1. Dendrimer in gene delivery Advanced drug delivery review, vol. 57 Dec 2005 page 2177–2202.

2. Immunological application of DNA Dendrimer, Clinical immunology vol. 119 supplements page196.

3. Dendrimer biomedical application –reflection on the field. Advanced drug delivery review, vol. 57 Dec 2005 page 2106–2129.

4. Dendrimers Biocompatibility and toxicity Advanced drug delivery review, vol. 57 Dec 2005 page 2177–2202.

5. Dendrimer and dendritic polymer in drug delivery drug discovery today, vol 10, Jan. 2005, page 35-43.

6. Virus based nanoparticals platform technologies for diagnostic imaging, advanced drug delivery reviews vol. 58 Dec 2006 page 1505- 1572.

7. A to Z Nanotechnology dendrimer definition, dendrimer in medicine, other industry application and examples of product.

8. Synthesis, characterization and stability of dendrimer prodrug, international journal of pharmaceutics, vol. 308,Feb 2006, page 175 –182.

9. In vitro biological evaluation of high molecular weight hyper branched polyglycerol.biomaterials, vol. 28 issue 32 Nov 2007 page no 4797-4787.

10.Biological properties of low molecular mass peptide dendrimer, international journal of pharmaceutics, vol. 309, Feb 2006, page 208-217 .

Comments

Add New Search RSS

Zdravko - Great Article   | Administrator | 2008-01-26 19:11:37 Thank you for sharing this great article at Farmavita.Net. Your contribution is very welcomed. Regards, Zdravko

Only registered users can write comments!

Powered by !JoomlaComment 3.12

Copyright (C) 2007 Alain Georgette / Copyright (C) 2006 Frantisek Hliva. All rights reserved.

• Leading Drug Delivery Companies and Technologies (14/10/2008)
• Cytotoxic Therapy Cancer Brands (09/10/2008)
• Targeted Therapy Cancer Brands (07/10/2008)

• CALONYCTION MURICATUM (18/01/2008)
• India - Survey of Computer Skills (23/12/2007)
• Acne Therapy (22/12/2007)

• Proteomics (15/12/2007)
• PHARMACOSOMES (11/12/2007)
• Nanotubes Against Cancer (08/12/2007)
• A Breakthrough on Stem Cells (20/11/2007)
• Antimalarial Drugs (18/11/2007)
• Medicinal Herbs (07/08/2007)
• Skin Cancer Therapy (27/05/2007)
• Surveillance of some recent proton pump inhibitors (22/04/2007)
• Wounds Healing (28/12/2006)

---